Esmya® Mode of Action

Esmya® is an oral Selective Progesterone Receptor Modulator (SPRM) characterized by a tissue‑specific partial progesterone antagonist effect1.

Esmya® directly acts on the endometrium, the fibroids and the pituitary gland1.

Endometrium Histological changes lead to reduced uterine bleeding
Fibroids Blockade of progesterone receptors, inhibition of cell proliferation and induction of
apoptosis reduces their size
Pituitary gland Ovulation is inhibited, LH and FSH secretion is partially suppressed, and mid-follicular
oestrogen levels are maintained

FSH, follicle-stimulating hormone; LH, luteinising hormone

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